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Modular and configurable optimal sequence alignment software: Cola

BACKGROUND: The fundamental challenge in optimally aligning homologous sequences is to define a scoring scheme that best reflects the underlying biological processes. Maximising the overall number of matches in the alignment does not always reflect the patterns by which nucleotides mutate. Efficient...

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Autori principali: Zamani, Neda, Sundström, Görel, Höppner, Marc P, Grabherr, Manfred G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064277/
https://ncbi.nlm.nih.gov/pubmed/24976859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1751-0473-9-12
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