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Deficiency of p110δ Isoform of the Phosphoinositide 3 Kinase Leads to Enhanced Resistance to Leishmania donovani

BACKGROUND: Visceral leishmaniasis is the most clinically relevant and dangerous form of human leishmaniasis. Most traditional drugs for treatment of leishmaniasis are toxic, possess many adverse reactions and drug resistance is emerging. Therefore, there is urgent need for identification of new the...

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Main Authors: Khadem, Forough, Mou, Zhirong, Liu, Dong, Varikuti, Sanjay, Satoskar, Abhay, Uzonna, Jude E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063731/
https://ncbi.nlm.nih.gov/pubmed/24945303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002951
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