Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem Repeats

Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a targeted approach to perform accurate measurement of tandem repeats even at extremely high copy number, and apply this techn...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Brahmachary, Manisha, Guilmatre, Audrey, Quilez, Javier, Hasson, Dan, Borel, Christelle, Warburton, Peter, Sharp, Andrew J.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2014
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063668/
https://ncbi.nlm.nih.gov/pubmed/24945355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004418
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