MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen

Toll-like receptors (TLRs) directly induce innate host defense responses, but the mechanisms of TLR-mediated adaptive immunity remain subject to debate. In this study, we clarified a role of TLR-mediated innate immunity for induction of adaptive immunity by oral vaccination with a live recombinant a...

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Autores principales: Park, Sung-Moo, Ko, Hyun-Jung, Shim, Doo-Hee, Yang, Jin-Young, Park, Yong-Ho, Curtiss, Roy, Kweon, Mi-Na
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063294/
https://ncbi.nlm.nih.gov/pubmed/18941235
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