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A toggle-switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins

Immature dengue virus particles undergo a dramatic conformational change upon exposure to the acidic environment of the late secretory pathway. The interactions of the E fusion proteins and prM chaperone proteins on the virus envelope are reorganized to permit prM processing by a host protease, furi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zheng, Aihua, Yuan, Fei, Kleinfelter, Lara M., Kielian, Margaret
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063126/
https://ncbi.nlm.nih.gov/pubmed/24846574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4877
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