Conversion of Androgen Receptor Signaling From a Growth Suppressor in Normal Prostate Epithelial Cells to an Oncogene in Prostate Cancer Cells Involves a Gain of Function in c-Myc Regulation

In normal prostate, androgen-dependent androgen receptor (AR) signaling within prostate stromal cells induces their secretion of paracrine factors, termed “andromedins” which stimulate growth of the epithelial cells. The present studies demonstrate that androgen-dependent andromedin-driven growth st...

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Bibliographische Detailangaben
Hauptverfasser: Vander Griend, Donald J., Litvinov, Ivan V., Isaacs, John T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062956/
https://ncbi.nlm.nih.gov/pubmed/24948876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.8756
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