Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

Imperfect maintenance of genome integrity has been postulated to be an important cause of aging. Here we provide support for this hypothesis by demonstrating that the disruption of PASG (lsh), a SNF2-like factor that facilitates DNA methylation, causes global hypomethylation, developmental growth re...

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Detalhes bibliográficos
Main Authors: Sun, Lin-Quan, Lee, David W., Zhang, Quangeng, Xiao, Weihong, Raabe, Eric H., Meeker, Alan, Miao, Dengshun, Huso, David L., Arceci, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC406293/
https://ncbi.nlm.nih.gov/pubmed/15105378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1176104
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