Inhibitors of second messenger pathways and Ca(2+)-induced exposure of phosphatidylserine in red blood cells of patients with sickle cell disease

The present work investigates the contribution of various second messenger systems to Ca(2+)-induced phosphatidylserine (PS) exposure in red blood cells (RBCs) from sickle cell disease (SCD) patients. The Ca(2+) dependence of PS exposure was confirmed using the Ca(2+) ionophore bromo-A23187 to clamp...

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Main Authors: Gbotosho, O. T., Cytlak, U. M., Hannemann, A., Rees, D. C., Tewari, S., Gibson, J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Signaling and Cell Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062833/
https://ncbi.nlm.nih.gov/pubmed/24158429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-013-1343-8
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