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The Biological Actions of 11,12-Epoxyeicosatrienoic Acid in Endothelial Cells Are Specific to the R/S-Enantiomer and Require the G(s) Protein

Cytochrome P450–derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis. Because many actions of 11,12-cis-epoxyeicosatrienoic acid (EET) are dependent on the activation of...

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Main Authors: Ding, Yindi, Frömel, Timo, Popp, Rüdiger, Falck, John R., Schunck, Wolf-Hagen, Fleming, Ingrid
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062412/
https://ncbi.nlm.nih.gov/pubmed/24763066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214254
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