Amerindian-specific regions under positive selection harbour new lipid variants in Latinos

Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican–Americans, which predispose these populations to cardiovascular disease. Here we design an approach, known as the cross-population allele screen (CPAS), which we conduct prior to a genome-wi...

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Detalhes bibliográficos
Main Authors: Ko, Arthur, Cantor, Rita M., Weissglas-Volkov, Daphna, Nikkola, Elina, Reddy, Prasad M. V. Linga, Sinsheimer, Janet S., Pasaniuc, Bogdan, Brown, Robert, Alvarez, Marcus, Rodriguez, Alejandra, Rodriguez-Guillen, Rosario, Bautista, Ivette C., Arellano-Campos, Olimpia, Muñoz-Hernández, Linda L., Salomaa, Veikko, Kaprio, Jaakko, Jula, Antti, Jauhiainen, Matti, Heliövaara, Markku, Raitakari, Olli, Lehtimäki, Terho, Eriksson, Johan G., Perola, Markus, Lohmueller, Kirk E., Matikainen, Niina, Taskinen, Marja-Riitta, Rodriguez-Torres, Maribel, Riba, Laura, Tusie-Luna, Teresa, Aguilar-Salinas, Carlos A., Pajukanta, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062071/
https://ncbi.nlm.nih.gov/pubmed/24886709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4983
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