White Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors

Periventricular leukomalacia (PVL) is the most frequent cause of cerebral palsy and other intellectual disabilities, and currently there is no treatment. In PVL, glutamate excitotoxicity (GME) leads to abnormal oligodendrocytes (OLs), myelin deficiency, and ventriculomegaly. We have previously ident...

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Huvudupphovsmän: Espinosa-Jeffrey, Araceli, Barajas, Socorro A. R., Arrazola, Alfonso R., Taniguchi, Alana, Zhao, Paul M., Bokhoor, Payam, Holley, Sandra M., Dejarme, Don P., Chu, Brian, Cepeda, Carlos, Levine, Michael S., Gressens, Pierre, Feria-Velasco, Alfredo, de Vellis, Jean
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061895/
https://ncbi.nlm.nih.gov/pubmed/24961618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci3041461
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