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Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis

Reactive oxygen species (ROS) have been implemented in the etiology of pulmonary fibrosis (PF) in systemic sclerosis. In the bleomycin model, we evaluated the role of acquired mutations in mitochondrial DNA (mtDNA) and respiratory chain defects as a trigger of ROS formation and fibrogenesis. Adult m...

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Detalhes bibliográficos
Main Authors: Gazdhar, Amiq, Lebrecht, Dirk, Roth, Michael, Tamm, Michael, Venhoff, Nils, Foocharoen, Chingching, Geiser, Thomas, Walker, Ulrich A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061543/
https://ncbi.nlm.nih.gov/pubmed/24939573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05336
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