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Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation...

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Detalhes bibliográficos
Main Authors: Gilbane, Adrian J, Denton, Christopher P, Holmes, Alan M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060542/
https://ncbi.nlm.nih.gov/pubmed/23796020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4230
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