Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

INTRODUCTION: The efficacy of pegloticase, a polyethylene glycol (PEG)-conjugated mammalian recombinant uricase, approved for chronic refractory gout, can be limited by the development of antibodies (Ab). Analyses from 2 replicate, 6-month, randomized controlled trials were performed to characterize...

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Main Authors: Lipsky, Peter E, Calabrese, Leonard H, Kavanaugh, Arthur, Sundy, John S, Wright, David, Wolfson, Marsha, Becker, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060440/
https://ncbi.nlm.nih.gov/pubmed/24588936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4497
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