Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

INTRODUCTION: Currently, there is huge research focus on the development of novel cell-based regeneration and tissue-engineering therapies for the treatment of intervertebral disc degeneration and the associated back pain. Both bone marrow-derived (BM) mesenchymal stem cells (MSCs) and adipose-deriv...

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Main Authors: Clarke, Louise E, McConnell, James C, Sherratt, Michael J, Derby, Brian, Richardson, Stephen M, Hoyland, Judith A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060243/
https://ncbi.nlm.nih.gov/pubmed/24618041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4505
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