Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers

BACKGROUND: Novel and targetable mutations are needed for improved understanding and treatment of lung cancer in never-smokers. METHODS: Twenty-seven lung adenocarcinomas from never-smokers were sequenced by both exome and mRNA-seq with respective normal tissues. Somatic mutations were detected and...

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Autori principali: Sun, Zhifu, Wang, Liang, Eckloff, Bruce W, Deng, Bo, Wang, Yi, Wampfler, Jason A, Jang, JinSung, Wieben, Eric D, Jen, Jin, You, Ming, Yang, Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060138/
https://ncbi.nlm.nih.gov/pubmed/24894543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-32
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