Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism

Autism-like phenotypes in male valproate (VPA)-exposed offspring have been linked to high glutamatergic neurotransmission in the thalamic-amygdala pathway. Glial cystine/glutamate exchange (system Xc(−)), which exchanges extracellular cystine for intracellular glutamate, plays a significant role in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Yu-Wen, Lin, Hui-Ching, Ng, Ming-Chong, Hsiao, Ya-Hsin, Wang, Chao-Chuan, Gean, Po-Wu, Chen, Po See
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060031/
https://ncbi.nlm.nih.gov/pubmed/24987341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00219
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