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Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles
The Val158Met polymorphism of human catechol-o-methyltransferase (COMT) is one of the most well-studied single-nucleotide polymorphisms in neuropsychiatry; however, findings are inconsistent due to human genetic heterogeneity. We created the first ‘humanized' COMTVal158Met mouse lines, which ca...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059890/ https://ncbi.nlm.nih.gov/pubmed/24509724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.29 |
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