Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

We performed a loss-of-function, RNA interference screen to define therapeutic targets in multiple myeloma, a genetically diverse plasma cell malignancy. Unexpectedly, we discovered that all myeloma lines require caspase-10 for survival, irrespective of their genetic abnormalities. The transcription...

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Detalhes bibliográficos
Main Authors: Lamy, Laurence, Ngo, Vu N., Emre, Tolga N. C., Shaffer, Arthur L., Yang, Yandan, Tian, Erming, Nair, Vinod, Kruhlak, Michael J., Zingone, Adriana, Landgren, Ola, Staudt, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059832/
https://ncbi.nlm.nih.gov/pubmed/23541952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.02.017
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