An LQTS6 MiRP1 Mutation Suppresses Pacemaker Current and is Associated with Sinus Bradycardia

BACKGROUND: Sinus node (SN) dysfunction is observed in some Long QT syndrome (LQTS) patients, but has not been studied as a function of LQTS genotype. LQTS6 involves mutations in the hERG β-subunit MiRP1, which also interacts with hyperpolarization-activated, cyclic nucleotide gated (HCN) channels -...

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Main Authors: Nawathe, Pooja A., Kryukova, Yelena, Oren, Ronit V., Milanesi, Raffaella, Clancy, Colleen E., Lu, Jonathan T., Moss, Arthur J., DiFrancesco, Dario, Robinson, Richard B.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059362/
https://ncbi.nlm.nih.gov/pubmed/23631727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jce.12163
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