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Termination Factor Rho and Its Cofactors NusA and NusG Silence Foreign DNA in E. coli

Transcription of the bacterial genome by the RNA polymerase must terminate at specific points. Transcription can be terminated by Rho factor, an essential protein in enterobacteria. We utilized the antibiotic bicyclomycin, which inhibits Rho, to assess its role on a genome-wide scale. Rho is a globa...

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Bibliographic Details
Main Authors: Cardinale, Christopher J., Washburn, Robert S., Tadigotla, Vasisht R., Brown, Lewis M., Gottesman, Max E., Nudler, Evgeny
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059013/
https://ncbi.nlm.nih.gov/pubmed/18487194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152763
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