MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports, including ours, indicated that miR-33a located within the intron of sterol regulatory element-binding protein (SREBP) 2 controls cholesterol homeostasis...

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Hauptverfasser: Horie, Takahiro, Nishino, Tomohiro, Baba, Osamu, Kuwabara, Yasuhide, Nakao, Tetsushi, Nishiga, Masataka, Usami, Shunsuke, Izuhara, Masayasu, Nakazeki, Fumiko, Ide, Yuya, Koyama, Satoshi, Sowa, Naoya, Yahagi, Naoya, Shimano, Hitoshi, Nakamura, Tomoyuki, Hasegawa, Koji, Kume, Noriaki, Yokode, Masayuki, Kita, Toru, Kimura, Takeshi, Ono, Koh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058878/
https://ncbi.nlm.nih.gov/pubmed/24931346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05312
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