Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Nitric oxide (NO) has pivotal roles in cyclophosphamide- (CYP-) induced cystitis during which mucosal nitric oxide synthase (NOS) and muscarinic M5 receptor expressions are upregulated. In cystitis, urothelial muscarinic NO-linked effects hamper contractility. Therefore we wondered if a blockade of...

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Main Authors: Aronsson, Patrik, Vesela, Renata, Johnsson, Martin, Tayem, Yasin, Wsol, Vladimir, Winder, Michael, Tobin, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058690/
https://ncbi.nlm.nih.gov/pubmed/24982868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/359179
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