Vasoinhibins Prevent Bradykinin-Stimulated Endothelial Cell Proliferation by Inactivating eNOS via Reduction of both Intracellular Ca(2+) Levels and eNOS Phosphorylation at Ser(1179)

Vasoinhibins, a family of antiangiogenic peptides derived from prolactin proteolysis, inhibit the vascular effects of several proangiogenic factors, including bradykinin (BK). Here, we report that vasoinhibins block the BK-induced proliferation of bovine umbilical vein endothelial cells. This effect...

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Main Authors: Thebault, Stéphanie, González, Carmen, García, Celina, Zamarripa, David Arredondo, Nava, Gabriel, Vaca, Luis, López-Casillas, Fernando, de la Escalera, Gonzalo Martínez, Clapp, Carmen
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058677/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph4071052
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