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Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats

RATIONALE: The noncompetitive NMDA antagonist ketamine produces rapid antidepressant effects in treatment-resistant patients suffering from major depressive and bipolar disorders. However, abuse liability is a concern. OBJECTIVES: This study examined abuse-related effects of keta-mine using intracra...

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Detalhes bibliográficos
Main Authors: Hillhouse, Todd M., Porter, Joseph H., Negus, S. Stevens
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058412/
https://ncbi.nlm.nih.gov/pubmed/24522331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3451-3
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