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Identification of mTORC2 as a Necessary Component of HRG/ErbB2-dependent Cellular Transformation
Over-expression of the receptor tyrosine kinase HER2/ErbB2 (ERBB2) has been linked to a poor prognosis for breast cancer patients; thus, its activity is a central target for cancer therapy. Likewise, over-expression of heregulin (HRG/NRG1), a growth factor responsible for ErbB2 activation, has also...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4058364/ https://ncbi.nlm.nih.gov/pubmed/24615340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0555 |
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