Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer

INTRODUCTION: Interleukin-6 (IL-6) can activate downstream signaling pathways in lung cancer cells, such as the STAT3 pathway, and is reported to be produced by tumor cells with activating EGFR mutations. We examined IL-6/STAT3 in lung cancer tumor tissues and the effects of siltuximab, a neutralizi...

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Main Authors: Song, Lanxi, Smith, Matthew A., Doshi, Parul, Sasser, Kate, Fulp, William, Altiok, Soner, Haura, Eric B.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057975/
https://ncbi.nlm.nih.gov/pubmed/24922005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000193
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