Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells

Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-γ-cyclodextrin). The complex was physico-chemically...

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Detalhes bibliográficos
Main Authors: Soica, Codruta, Danciu, Corina, Savoiu-Balint, Germaine, Borcan, Florin, Ambrus, Rita, Zupko, Istvan, Bojin, Florina, Coricovac, Dorina, Ciurlea, Sorina, Avram, Stefana, Dehelean, Cristina Adriana, Olariu, Teodora, Matusz, Petru
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057729/
https://ncbi.nlm.nih.gov/pubmed/24821543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15058235
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