Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

INTRODUCTION: Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of epigenetic regulation within breast cancer cells, such as DNA methylation, resulting in changed mRNA expression of genes piv...

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Main Authors: Lin, Xue, Li, Jian, Yin, Guangliang, Zhao, Qian, Elias, Daniel, Lykkesfeldt, Anne E, Stenvang, Jan, Brünner, Nils, Wang, Jun, Yang, Huanming, Bolund, Lars, Ditzel, Henrik J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057522/
https://ncbi.nlm.nih.gov/pubmed/24355041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3588
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