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Increased Growth-Inhibitory and Cytotoxic Activity of Arsenic Trioxide in Head and Neck Carcinoma Cells with Functional p53 Deficiency and Resistance to EGFR Blockade

BACKGROUND AND PURPOSE: Mutations in the p53 gene are frequently observed in squamous cell carcinoma of the head and neck region (SCCHN) and have been associated with drug resistance. The potential of arsenic trioxide (ATO) for treatment of p53-deficient tumor cells and those with acquired resistanc...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Boyko-Fabian, Mariya, Niehr, Franziska, Distel, Luitpold, Budach, Volker, Tinhofer, Ingeborg
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057125/
https://ncbi.nlm.nih.gov/pubmed/24927258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098867
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