MHC-Matched Induced Pluripotent Stem Cells Can Attenuate Cellular and Humoral Immune Responses but Are Still Susceptible to Innate Immunity in Pigs

Recent studies have revealed negligible immunogenicity of induced pluripotent stem (iPS) cells in syngeneic mice and in autologous monkeys. Therefore, human iPS cells would not elicit immune responses in the autologous setting. However, given that human leukocyte antigen (HLA)-matched allogeneic iPS...

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Detalhes bibliográficos
Main Authors: Mizukami, Yoshihisa, Abe, Tomoyuki, Shibata, Hiroaki, Makimura, Yukitoshi, Fujishiro, Shuh-hei, Yanase, Kimihide, Hishikawa, Shuji, Kobayashi, Eiji, Hanazono, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057111/
https://ncbi.nlm.nih.gov/pubmed/24927426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098319
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