Apical constriction and invagination downstream of the canonical Wnt signaling pathway requires Rho1 and Myosin II

The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt signaling and functions in cytoskeletal organization. Disruption of human APC in colonic epithelia initiates benign polyps that progress to carcinoma following additional mutations. The early events of polyposis are...

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Bibliografiske detaljer
Main Authors: Zimmerman, Sandra G., Thorpe, Lauren M., Medrano, Vilma R., Mallozzi, Carolyn A., McCartney, Brooke M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056678/
https://ncbi.nlm.nih.gov/pubmed/20102708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.01.021
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