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AZD-3043: A Novel, Metabolically-Labile Sedative/Hypnotic Agent with Rapid and Predictable Emergence from Hypnosis

BACKGROUND: Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid(A) (GABA(A)) receptor containing a metabolically-labile ester moiety....

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Detalhes bibliográficos
Main Authors: Egan, Talmage D., Obara, Shinju, Jenkins, Thomas E., Jaw-Tsai, Sarah S., Amagasu, Shanti, Cook, Daniel R., Steffensen, Scott C., Beattie, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056591/
https://ncbi.nlm.nih.gov/pubmed/22531340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31825685a6
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