Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

BACKGROUND: Metastatic triple-negative breast cancer is mostly incurable, due to lack of suitable drug targets. The insulin-like growth factor (IGF) system could provide such a target, and IGF-1 receptor (IGF-1R)-directed agents are already available, but seem unable to control all the complexities...

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Detalhes bibliográficos
Main Authors: Mancini, M, Gariboldi, M B, Taiana, E, Bonzi, M C, Craparotta, I, Pagin, M, Monti, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056066/
https://ncbi.nlm.nih.gov/pubmed/24853185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.269
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