The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)

Multiple myeloma confers a high risk for vascular thrombosis, a risk that is increased by treatment with immunomodulatory agents. Strikingly, inclusion of the proteasome inhibitor bortezomib reduces thrombotic risk, yet the molecular basis for this observation remains unknown. Here, we show that bor...

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Bibliografiske detaljer
Main Authors: Nayak, Lalitha, Shi, Hong, Atkins, G. Brandon, Lin, Zhiyong, Schmaier, Alvin H., Jain, Mukesh K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055929/
https://ncbi.nlm.nih.gov/pubmed/24771858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-547448
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