Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused by Staphylococcus aureus. S. aureus is the primary cause of acute bacterial skin and soft tissue infections (SSTIs) and the quorum sensing ope...

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Autori principali: Sully, Erin K., Malachowa, Natalia, Elmore, Bradley O., Alexander, Susan M., Femling, Jon K., Gray, Brian M., DeLeo, Frank R., Otto, Michael, Cheung, Ambrose L., Edwards, Bruce S., Sklar, Larry A., Horswill, Alexander R., Hall, Pamela R., Gresham, Hattie D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055767/
https://ncbi.nlm.nih.gov/pubmed/24945495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004174
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