Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded Kinases

The simultaneous targeting of host and pathogen processes represents an untapped approach for the treatment of intracellular infections. Hypoxia-inducible factor-1 (HIF-1) is a host cell transcription factor that is activated by and required for the growth of the intracellular protozoan parasite Tox...

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Hlavní autoři: Brown, Kevin M., Suvorova, Elena, Farrell, Andrew, McLain, Aaron, Dittmar, Ashley, Wiley, Graham B., Marth, Gabor, Gaffney, Patrick M., Gubbels, Marc Jan, White, Michael, Blader, Ira J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055737/
https://ncbi.nlm.nih.gov/pubmed/24945800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004180
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