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A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion

Matrix metalloproteinase-9 (MMP-9) plays key roles in the brain pathophysiology, especially in blood-brain barrier (BBB) breakdown. Therefore, inhibiting MMP-9 activity may be a promising therapy for protecting brains in cerebrovascular diseases. Here we show that in a mouse prolonged cerebral hypop...

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Detalhes bibliográficos
Main Authors: Miyamoto, Nobukazu, Pham, Loc-Duyen D., Maki, Takakuni, Liang, Anna C., Arai, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055517/
https://ncbi.nlm.nih.gov/pubmed/24820542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.05.005
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