The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)

BACKGROUND AND PURPOSE: Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygenase (5-LOX) pathway and are linked to diverse disorders, including asthma, allergic rhinitis and cardiovascular diseases. We recently identified the benzimidazole derivative BRP-7 as chemotype for anti-...

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Bibliographic Details
Main Authors: Pergola, C, Gerstmeier, J, Mönch, B, Çalışkan, B, Luderer, S, Weinigel, C, Barz, D, Maczewsky, J, Pace, S, Rossi, A, Sautebin, L, Banoglu, E, Werz, O
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055205/
https://ncbi.nlm.nih.gov/pubmed/24641614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12625
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