Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling

INTRODUCTION: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired function of aged MSCs hampered the therapeutic efficacy of engrafted MSCs, an...

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Main Authors: Zhang, Zheng, Zhao, Chuanxu, Liu, Bing, Liang, Dong, Qin, Xing, Li, Xiujuan, Zhang, Rongqing, Li, Congye, Wang, Haichang, Sun, Dongdong, Cao, Feng
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055148/
https://ncbi.nlm.nih.gov/pubmed/24670364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt431
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