Knockdown of AKT3 (PKB γ) and PI3KCA Suppresses Cell Viability and Proliferation and Induces the Apoptosis of Glioblastoma Multiforme T98G Cells

Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor that is difficult to treat and has a very poor prognosis. Thus, new therapeutic strategies that target GBM are urgently needed. The PI3K/AKT/PTEN signaling pathway is frequently deregulated in a wide range of cancers....

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Detalhes bibliográficos
Main Authors: Paul-Samojedny, Monika, Suchanek, Renata, Borkowska, Paulina, Pudełko, Adam, Owczarek, Aleksander, Kowalczyk, Małgorzata, Machnik, Grzegorz, Fila-Daniłow, Anna, Kowalski, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054922/
https://ncbi.nlm.nih.gov/pubmed/24967401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/768181
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