Emergence of Hypervirulent Mutants Resistant to Early Clearance During Systemic Serotype 1 Pneumococcal Infection in Mice and Humans

Background. Streptococcus pneumoniae serotype 1 has a high likelihood of causing invasive disease. Serotype 1 isolates belonging to CC228 are associated with low mortality, while CC217 isolates exhibit high mortality in patients. Methods. Clinical pneumococcal isolates and mutants were evaluated in...

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Detalhes bibliográficos
Main Authors: Syk, Anna, Norman, Martin, Fernebro, Jenny, Gallotta, Marilena, Farmand, Susan, Sandgren, Andreas, Normark, Staffan, Henriques-Normark, Birgitta
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054898/
https://ncbi.nlm.nih.gov/pubmed/24443543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu038
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