Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis: A Murine Xenograft Model of Renal Cell Carcinoma

Background. Angiotensin-2 type-1 receptor antagonists not are only antihypertensive drugs but also can inhibit VEGF production. We hypothesised that adding telmisartan to sunitinib could potentiate the antiangiogenic effects. Material and Methods. 786-O cell lines were injected in nude mice. After t...

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Bibliographische Detailangaben
Hauptverfasser: Verhoest, Grégory, Dolley-Hitze, Thibault, Jouan, Florence, Belaud-Rotureau, Marc-Antoine, Oger, Emmanuel, Lavenu, Audrey, Bensalah, Karim, Arlot-Bonnemains, Yannick, Collet, Nicolas, Rioux-Leclercq, Nathalie, Vigneau, Cécile
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054801/
https://ncbi.nlm.nih.gov/pubmed/24967411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/901371
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