The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts

BACKGROUND: DNA methylation plays an essential role in the regulation of gene expression. While its presence near the transcription start site of a gene has been associated with reduced expression, the variation in methylation levels across individuals, its environmental or genetic causes, and its a...

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Autores principales: Wagner, James R, Busche, Stephan, Ge, Bing, Kwan, Tony, Pastinen, Tomi, Blanchette, Mathieu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053980/
https://ncbi.nlm.nih.gov/pubmed/24555846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-2-r37
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