Reducing assembly complexity of microbial genomes with single-molecule sequencing

BACKGROUND: The short reads output by first- and second-generation DNA sequencing instruments cannot completely reconstruct microbial chromosomes. Therefore, most genomes have been left unfinished due to the significant resources required to manually close gaps in draft assemblies. Third-generation,...

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Detalhes bibliográficos
Main Authors: Koren, Sergey, Harhay, Gregory P, Smith, Timothy PL, Bono, James L, Harhay, Dayna M, Mcvey, Scott D, Radune, Diana, Bergman, Nicholas H, Phillippy, Adam M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053942/
https://ncbi.nlm.nih.gov/pubmed/24034426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-9-r101
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