Dose-Dependent Effect of Estrogen Suppresses the Osteo-Adipogenic Transdifferentiation of Osteoblasts via Canonical Wnt Signaling Pathway

Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produc...

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Main Authors: Gao, Bo, Huang, Qiang, Lin, Yan-Shui, Wei, Bo-Yuan, Guo, Yun-Shan, Sun, Zhen, Wang, Long, Fan, Jing, Zhang, Hong-Yang, Han, Yue-Hu, Li, Xiao-Jie, Shi, Jun, Liu, Jian, Yang, Liu, Luo, Zhuo-Jing
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053448/
https://ncbi.nlm.nih.gov/pubmed/24918446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099137
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