Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.
Cassette mutagenesis was used to identify side chains in human interleukin 5 (hIL-5) that mediate binding to hIL-5 receptor alpha chain (hIL-5R alpha). A series of single alanine substitutions was introduced into a stretch of residues in the C-terminal region, including helix D, which previously had...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10879 |
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