Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

INTRODUCTION: Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (mTORC1), which regulate cell-cycle progression an...

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Main Authors: Martin, Lesley-Ann, Pancholi, Sunil, Farmer, Ian, Guest, Stephanie, Ribas, Ricardo, Weigel, Marion T, Thornhill, Allan M, Ghazoui, Zara, A'Hern, Roger, Evans, Dean B, Lane, Heidi A, Johnston, Stephen R, Dowsett, Mitch
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053110/
https://ncbi.nlm.nih.gov/pubmed/23075476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3330
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