Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

INTRODUCTION: Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (mTORC1), which regulate cell-cycle progression an...

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Bibliografski detalji
Glavni autori: Martin, Lesley-Ann, Pancholi, Sunil, Farmer, Ian, Guest, Stephanie, Ribas, Ricardo, Weigel, Marion T, Thornhill, Allan M, Ghazoui, Zara, A'Hern, Roger, Evans, Dean B, Lane, Heidi A, Johnston, Stephen R, Dowsett, Mitch
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053110/
https://ncbi.nlm.nih.gov/pubmed/23075476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3330
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