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Comparisons of Interfacial Phe, Tyr, and Trp Residues as Determinants of Orientation and Dynamics for GWALP Transmembrane Peptides

[Image: see text] Aromatic amino acids often flank the transmembrane alpha helices of integral membrane proteins. By favoring locations within the membrane–water interface of the lipid bilayer, aromatic residues Trp, Tyr, and sometimes Phe may serve as anchors to help stabilize a transmembrane orien...

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Bibliographische Detailangaben
Hauptverfasser: Sparks, Kelsey A., Gleason, Nicholas J., Gist, Renetra, Langston, Rebekah, Greathouse, Denise V., Koeppe, Roger E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053069/
https://ncbi.nlm.nih.gov/pubmed/24829070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500439x
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