Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

INTRODUCTION: DNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene encodes protein kinase D1 (PKD1), a serine/threonine kinase that is expres...

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Detalhes bibliográficos
Main Authors: Borges, Sahra, Döppler, Heike, Perez, Edith A, Andorfer, Cathy A, Sun, Zhifu, Anastasiadis, Panos Z, Thompson, E Aubrey, Geiger, Xochiquetzal J, Storz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052945/
https://ncbi.nlm.nih.gov/pubmed/23971832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3460
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